Purified anti-mouse CD5 Antibody Lyt-1 / Ly-1 / T1 / Tp67 / Ly-12
Purified anti-mouse CD5 Antibody Lyt-1 / Ly-1 / T1 / Tp67 / Ly-12
种 属：Mouse
商品编号：GX00002A
商品库存：100支　浏览：1221 次
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Other Names:Lyt-1, Ly-1, T1, Tp67, Ly-12

IsotypeRat IgG2a, κAve. 


Description

CD5 is a 67 kD protein, also known as Lyt-1, Ly-1, T1, Tp67, or Ly-12. It is a member of the scavenger receptor cysteine-rich protein superfamily (SRCR) and primarily expressed on thymocytes, T cells, and B-1 cells. Although mature α/β T cells express high levels of CD5, very few γ/δ T cells express this antigen. The interaction of CD5 with CD72, gp35-37, TCR, or BCR is involved in T and B cell activation.



Product Details

Isotype Control Purified Rat IgG2a, κ Isotype Ctrl Verified ReactivityMouseAntibody TypeMonoclonalHost SpeciesRatImmunogenMouse thymus or spleenFormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.PreparationThe antibody was purified by affinity chromatography.Concentration0.5 mg/ml
Storage & HandlingThe antibody solution should be stored undiluted between 2°C and 8°C.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, and immunohistochemistry2 of acetone-fixed frozen tissue sections, zinc-fixed paraffin-embedded sections and formalin-fixed paraffin-embedded sections.


Product Citations
  1. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  2. Kang YA, et al. 2023. J Exp Med. 220:. PubMed
  3. Seifert HA, et al. 2018. Metab Brain Dis. 33:1599. PubMed
  4. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  5. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  6. Niss Arfelt K, et al. 2017. Blood. 129:866. PubMed
  7. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  8. Doorduijn EM, et al. 2018. Front Immunol. 0.416666667. PubMed
  9. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  10. Formaglio P, et al. 2021. Immunity. 54:2724. PubMed
  11. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  12. Sprouse ML, et al. 2018. JCI Insight. 3:e97322. PubMed


Antigen Details

StructureMember of the scavenger receptor cysteine-rich protein superfamily (SRCR), 67 kDDistribution

Thymocytes, T cells, B-1 cells

FunctionNegative regulator of T-B cell interactionLigand/ReceptorCD72, gp35-37Cell TypeB cells, T cells, ThymocytesBiology AreaCostimulatory Molecules, ImmunologyMolecular FamilyCD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Kipps TJ. 1988. Adv. Immunol. 47:117.
3. Antin JH, et al. 1985. J. Immunol. 136:505.
4. Tarakhovsky A, et al. 1995. Science 269:535.

Gene ID 12507 

UniProt View information about CD5 on UniProt.org