研究方向
碳酸酐酶 1 (CA1) 是碳酸酐酶 (CA) 家族的成员，可可逆地催化 CO2 水合形成 HCO3-，然后迅速与钙离子结合形成碳酸钙。CA1 在人类 AS 组织和 β-磷酸甘油诱导钙化的大鼠血管平滑肌细胞 (VSMC) 中也高表达。
Ala2-Phe261, with a C-terminal 10-His tag
Analysis
30 kDa, reducing conditions
Background: Carbonic Anhydrase I/CA1
Carbonic Anhydrase (CA) catalyzes the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption . Topics in a CA meeting (6th International Conference on the CAs, June 20-25, 2003, Slovakia) ranged from use of CAs as markers for tumor and hypoxia in clinic, as nutritional supplement in milk, and as a tool for CO2 removal and mosquito control in industry. CA1 is a cytosolic enzyme with the highest levels in erythrocytes and is a very early marker for erythroid differentiation . The activity of CA1 can also be measured by its ability to catalyze the reaction CO2 + H2O → HCO3- + H+, using a published method .