Human VSIG9(V-Set and Immunoglobulin Domain Containing 9),也称为 TIGIT(T cell immunoreceptor with Ig and ITIM domains),是一种免疫调节受体,属于免疫球蛋白超家族(IgSF)。它在免疫抑制和免疫耐受中发挥重要作用,尤其是在调节T细胞和自然杀伤(NK)细胞的功能中。
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商品编号: GX00447 库存: 100支
上市时间: 2024-12-11 16:37:27 浏览次数: 1036次
研究方向
Human VSIG9(V-Set and Immunoglobulin Domain Containing 9),也称为 TIGIT(T cell immunoreceptor with Ig and ITIM domains),是一种免疫调节受体,属于免疫球蛋白超家族(IgSF)。它在免疫抑制和免疫耐受中发挥重要作用,尤其是在调节T细胞和自然杀伤(NK)细胞的功能中。以下是关于VSIG9/TIGIT的详细信息:
Human VSIG9/TIGIT是一种重要的免疫抑制受体,通过与CD155和CD112结合,在免疫调节、肿瘤免疫逃逸和感染应答中发挥关键作用。其作为肿瘤免疫治疗和自身免疫疾病治疗的新靶点,具有重要的研究和临床应用价值。
Immobilized Human TIGIT at 1.5 μg/mL (100 μL/well) can bind Human CD155 with a linear range of 0.15-1.2 μg/mL.
This protein is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The protein is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.