研究方向
作为 TGF-β-2 信号通路的核心参与者，TGF-β2/TGFB2 蛋白承担潜伏相关肽 (LAP) 和转化生长因子 β-2 (TGF-β- 2）链条。这些链共同分别形成 TGF-β-2 的调节亚基和活性亚基。值得注意的是，TGF-β2/TGFB2 对于在细胞外基质内储存期间维持 TGF-β-2 链处于潜在状态至关重要。该蛋白与 TGF-β-2 进行非共价结合，通过与“环境分子”（包括 LTBP1 和 LRRC32/GARP）相互作用来复杂地调节其激活。这些相互作用在控制 TGF-β-2 的激活中发挥着关键作用，有助于这一关键信号通路的精细调节。
Measured by its ability to inhibit the IL-4- dependent proliferation of HT‑2 mouse T cells. The ED50 for this effect is 20-100 ng/mL.
This protein belongs a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
