研究方向
信号淋巴细胞激活分子 (SLAM),也称为 CD150,是含有免疫球蛋白 (Ig) 结构域的分子 CD2 蛋白家族的成员,在多种造血细胞的表面表达。SLAM家族成员现在被认为是重要的免疫调节受体,在细胞毒性、体液免疫、自身免疫、细胞存活、淋巴细胞发育和细胞粘附中发挥作用。SLAM 可以充当 MV 疫苗和野生型毒株的细胞受体。
Measured by its ability to co-stimulate IL-4 secretion by D10.G4.1 mouse helper T cells in the presence of anti-CD3. The ED50 forthis effect is 0.6-2.4 μg/mL.
SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes ofSLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another inwhich protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.