活性重组蛋白 Recombinant Human SERPING1 / C1IN / C1INH / C1NH / HAE1 / HAE2 / serpin family G member 1 / C1IN / C1INH / C1NH / HAE1 / HAE2 Protein

研究方向

Serpin G1 也称为 C1 抑制剂，通过与 C1r 或 C1s 蛋白酶形成蛋白水解无活性的化学计量复合物来控制 C1 复合物的激活。这种相互作用凸显了其在调节重要生理途径（包括补体激活、凝血、纤维蛋白溶解和激肽生成）方面的潜在关键作用。作为 FXIIa 的高效抑制剂，它还可以抑制胰凝乳蛋白酶和激肽释放酶。值得注意的是，Serpin G1 与大肠杆菌 stcE 结合，促进其定位到细胞膜，从而保护细菌免受补体介导的裂解。此外，它还与 MASP1 结合，进一步促进其复杂地参与多种细胞过程。

Measured by its ability to inhibit Recombinant Human Complement Component C1s cleavage of a colorimetric peptide substrate, Ncarbobenzyloxy-Lys-ThioBenzyl ester(Z-K-SBzl). The IC50 is <5 nM, as measured underthe described conditions. 

Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin).Serpin G1/C1 inhibitor is the physiological inhibitor of activated C1r and C1s and regulates activation of both the complement and contact systems. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.