Galectin-3/LGALS3 蛋白是一种半乳糖特异性凝集素，以其在细胞过程中的多种作用而闻名。它结合 IgE，并与 α-3、β-1 整合素协同作用，促进 CSPG4 诱导的内皮细胞迁移。
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商品编号： GX004904 库存： 100支
上市时间： 2024-11-19 15:07:47 浏览次数： 580次
研究方向
Galectin-3/LGALS3 蛋白是一种半乳糖特异性凝集素，以其在细胞过程中的多种作用而闻名。它结合 IgE，并与 α-3、β-1 整合素协同作用，促进 CSPG4 诱导的内皮细胞迁移。与 DMBT1 一起，它对于早期胚胎发生过程中柱状上皮细胞的终末分化至关重要。在细胞核中，该蛋白作为前体 mRNA 剪接因子，积极参与急性炎症反应，影响中性粒细胞活化、粘附、单核细胞和巨噬细胞的化学吸引、凋亡中性粒细胞的调理作用和肥大细胞活化。它与 TRIM16 的合作可以协调识别膜损伤，触发核心自噬调节因子 ATG16L1 和 BECN1 的动员，以应对受损的内膜。该蛋白可能形成同源或异源二聚体，并与各种伙伴结合，包括 DMBT1、CD6、ALCAM、ITGA3、ITGB1、CSPG4、LGALS3BP、LYPD3、ZFTRAF1、UACA、TRIM16 和 TMED10，促进多种细胞相互作用，包括自噬和分泌。
When Recombinant Human Galectin-Human Galectin- 3BP/MAC-2BP is immobilizedat 0.5 µg/mL,100 μL/well, It can bind Recombinant Human Galectin‑3 with an ED50 of 0.2-1 μg/mL.
表达区间
19-585 aa
Galectin-3 binding protein (Galectin-3BP), also known as MAC-2 binding protein (MAC-2BP or M2BP), and the 90 kDa tumor associated antigen (TAA90K or 90K), is a secreted glycoprotein of the scavenger receptor cysteine-rich (SRCR) superfamily. Galectin-3BP binds Galectin-3 (formerly MAC-2) with high affinity, but also binds Galectins -1 and -7, several collagen types, fibronectin, beta 1 integrins and nidogen. It is widely expressed in all extracellular fluids and in pericellular areas of cell‑rich tissues. The 585 amino acid (aa) human Galectin‑3BP contains an 18 aa signal sequence and four definitive domains. Domain 1 is a group A scavenger receptor domain, domain 2 is a BTB/POZ domain that strongly mediates dimerization, and domain 3 is an IVR domain, that is also found following the POZ domain in Drosophila kelch protein. Although little is known about domain 4, recombinant domains 3 and 4 reproduce the solid‑phase adhesion profile of full‑length Galectin‑3BP. Glycosylation at seven N‑linked sites, generates a molecular size of 85‑97 kDa. Galectin‑3BP dimers form linear and ring‑shaped oligomers, most commonly decamers and dodecamers. In vitro, Galectin‑3BP has been shown to stimulate natural killer cells and lymphokine‑activated killer cell activity . High Galectin‑3BP expression has been correlated with tumor aggressiveness in several, but not all, study systems. Mature human Galectin‑3BP shares 69% aa identity with mouse cyclophilin C‑associated protein (CyCAP), which does not appear to bind Galectin‑3. Human Galectin‑3BP also shares 73%, 67% and 68% aa identity with relatively uncharacterized orthologs in dog, rat and cow, respectively. A human N‑terminally truncated sequence that begins within the BTB/POZ domain (aa 196) has been reported.
