研究方向
IL-1RL2 是白细胞介素 36（IL36A、IL36B 和 IL36G）的受体，在与白细胞介素 36 结合后参与复杂的信号转导事件。通过与辅助受体 IL1RAP 结合，形成白细胞介素 36 受体复合物，协调白细胞介素 36 依赖性的 NF-κ-B、MAPK 和其他途径的激活。该信号系统类似于 IL-1 系统，与上皮屏障内的局部炎症反应有关，特别是通过诱导 IL-23/IL-17/IL-22 途径促进皮肤炎症反应。
Measured by its ability to inhibit LPS-stimulated IL-8 secretion by HK-2 human kidney epithelial cells. The ED50 forthis effect is less than 1.25 μg/mL.
This protein is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
