活性重组蛋白 Recombinant Human IL23R / IBD17 / IL-23 R / IL-23 receptor Protein-武汉瑾萱生物科技有限公司商城首页

研究方向

IL-23R 蛋白在免疫反应中发挥着关键作用，因为它通过与 IL12RB1 结合形成白细胞介素 23 受体。它与 IL23 结合，并通过 Jak-Stat 信号级联触发 T 细胞、NK 细胞以及潜在的某些巨噬细胞/骨髓细胞的激活。IL23 参与先天性免疫和适应性免疫，并且可能有助于外周组织对感染的急性反应。此外，IL23 与自身免疫性炎症性疾病有关，并已被证明在肿瘤发生中发挥重要作用。当 IL12RB1 存在时，IL-23R 形成异二聚体，充当 IL-23 受体。它与 JAK2 相互作用，并且在 IL23 存在的情况下激活 STAT3。

生物活性

Immobilized Human IL- 12B&IL-23A at 5μg/mL (100μL/well) can bind Human IL23R with a linear range of 4-135 ng/ml.

种属

Human

表达宿主

HEK293 cells

Calculated MW

64.01 kDa

Observed MW

90-110 kDa

标签

C-hFc

纯度

> 95% by SDS-PAGE.

内毒素

<1EU/μg

制剂

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

描述

Recombinant Human IL-23R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Gly355) of human IL23R (Accession #NP_653302.2) fused with a hFc tag at the C-terminus.

储存

Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月；
复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。

复溶

Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.收到重组蛋白产品之后请检查蛋白冻干粉末是否贴于瓶底，如果粉末浮起，开盖之前请先低温离心。将蛋白用说明书中指定的缓冲液复溶至0.1-0.5 mg/mL（请注意蛋白复溶浓度不能低于0.1 mg/mL），室温平衡5-10 min保证充分溶解，复溶过程中请不要剧烈涡旋及吹打蛋白溶液。如需长期储存，建议复溶时添加载体蛋白或者稳定剂（如0.1% BSA, 5% HSA, 10% FBS 或者 5% 海藻糖），同时将复溶后的蛋白溶液按照需求进行分装，储存于-20°C至-80°C，随取随用，避免反复冻融。

背景信息

IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK, and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells, and possibly certain macrophage/myeloid cell stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

基因ID

149233

Swiss Prot

Q5VWK5-1

别名

IL23R,IL23R,IBD17,IL-23 R,IL-23 receptor

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活性重组蛋白 Recombinant Human IL23R / IBD17 / IL-23 R / IL-23 receptor Protein

背景信息

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