研究方向
Interleukin-22(IL-10相关T细胞衍生诱导因子/IL-TIF/IL-22)是属于IL-10家族的新型细胞因子。研究发现重组人 IL-22 (hIL-22) 可激活信号转导子和转录因子 1 和 3 的激活剂以及几种肝癌细胞系中的急性期反应物,表明其参与炎症反应。IL-22 是 IL-10 细胞因子家族的成员,除 IL-10 及其多种病毒同源物外,该家族还包括 IL-19、IL-20 和 IL-24。
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 160-640 pg/mL.
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.