活性重组蛋白 Recombinant Human IL1R1 / CD121A / D2S1473 / IL-1R-alpha / IL1R / IL1RA / P80 Protein

IL-1R1 (CD121a) 是 IL-1 受体的成员，是 IL-1α、IL-1β、IL-1Ra 和 IL-38 的受体，从而介导 IL-1 依赖性激活。IL-1R1 在特定的内皮细胞、心室细胞、星形胶质细胞和神经元中表达。

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商品分类：重组蛋白　　种属： Human

商品编号： GX004887　　库存： 100支

上市时间： 2024-11-18 12:02:35　　浏览次数： 567次

研究方向

IL-1R1 (CD121a) 是 IL-1 受体的成员，是 IL-1α、IL-1β、IL-1Ra 和 IL-38 的受体，从而介导 IL-1 依赖性激活。IL-1R1 在特定的内皮细胞、心室细胞、星形胶质细胞和神经元中表达。
不同物种的 IL-1R1 氨基酸序列不同。人 IL-1R1 与小鼠和大鼠的氨基酸序列一致性 <70%。
IL-1R1 通过与 IL-1R3 (IL-1RAcP) 形成异二聚体来与 IL-1 结合。异二聚体负责通过 GTP 水解进行信号转导，然后是 JNK 和 p38 MAP 激酶。与 IL-1 结合后，IL-1R1 启动下游信号级联（MAPK p38 和 NF-κB 通路）。IL-1R1 信号传导诱导人类 Th17 细胞分化和定型，这对于自身免疫性疾病的发展至关重要。
IL-1R1 介导免疫和炎症反应。IL-1R1介导NF-κB、MAPK通路的激活。

生物活性

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.2-1.0 µg/m with human IL-1 beta.

种属

Human

表达宿主

HEK293 cells

Calculated MW

62.9 kDa

Observed MW

80-105 kDa

标签

C-hFc

纯度

> 95% by SDS-PAGE.

内毒素

< 0.1 EU/μg of the protein by LAL method.

制剂

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.

描述

Recombinant Human IL-1R1/ CD121a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu18-Thr332) of human IL-1R1/ CD121a (Accession #P14778) fused with a hFc tag at the C-terminus.

储存

Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月；
复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。

复溶

Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.收到重组蛋白产品之后请检查蛋白冻干粉末是否贴于瓶底，如果粉末浮起，开盖之前请先低温离心。将蛋白用说明书中指定的缓冲液复溶至0.1-0.5 mg/mL（请注意蛋白复溶浓度不能低于0.1 mg/mL），室温平衡5-10 min保证充分溶解，复溶过程中请不要剧烈涡旋及吹打蛋白溶液。如需长期储存，建议复溶时添加载体蛋白或者稳定剂（如0.1% BSA, 5% HSA, 10% FBS 或者 5% 海藻糖），同时将复溶后的蛋白溶液按照需求进行分装，储存于-20°C至-80°C，随取随用，避免反复冻融。

背景信息

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor Type I is a potent antagonist of IL-1 action.

基因ID

3554

Swiss Prot

P14778

别名

IL1R1;CD121A;D2S1473;IL-1R-alpha;IL1R;IL1RA;P80

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活性重组蛋白 Recombinant Human IL1R1 / CD121A / D2S1473 / IL-1R-alpha / IL1R / IL1RA / P80 Protein

背景信息

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