研究方向
CEACAM1 蛋白参与多种生物过程。它在胰岛素刺激下被胰岛素受体(INSR)磷酸化,从而促进胰岛素清除并调节肝脏脂肪生成。SF3R基因参与多种生物过程和功能。它通过促进胰岛素的清除和调节肝脏中的脂肪生成来调节胰岛素的作用。在胰岛素刺激下,SF3R 会被胰岛素受体 (INSR) 磷酸化,导致胰岛素内吞作用和降解增加。这导致脂肪酸合成减少。SF3R 还通过与 SHC1 相互作用,在下调细胞增殖中发挥作用,从而减少 SHC1 与 MAPK3/ERK1-MAPK1/ERK2 和磷脂酰肌醇 3-激酶途径的偶联。
The protein encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.